RESUMO
Ascending aortic pseudoaneurysm is a rare complication after HT. Surgery is the most conventional management, but in some patients, it is risky. We report the case of a ten-year-old child who underwent HT and developed an ascending aortic pseudoaneurysm in the aortic anastomosis. He was successfully treated with two covered stents through endovascular management. Endovascular therapy is an alternative management in high-risk patients. To our knowledge, this is the first report about endovascular therapy of an AAP after HT in a pediatric patient.
Assuntos
Falso Aneurisma/cirurgia , Aorta/cirurgia , Procedimentos Endovasculares/métodos , Transplante de Coração , Complicações Pós-Operatórias/cirurgia , Criança , Humanos , MasculinoRESUMO
BACKGROUND: Heart failure (HF) prognosis without therapy is poor, however introduction of a range of drugs has improved it. We aimed to perform a systematic review on the effects and safety of sodium-glucose transporter 2 inhibitors (SGLT2i) in HF patients. METHODS: We carried out a systematic review of randomized controlled trials (RCTs) on SGLT2i compared to placebo for HF patients. We searched in PubMed, Scopus, Web of Science and EMBASE, with no language restriction, from inception to 31 August 2020. We included nine RCTs comprising three arms (empagliflozin, dapagliflozin and placebo). Effects sizes for continuous variables were expressed as mean differences (MDs) and 95% confidence intervals (CIs). Effects sizes for dichotomous variables were expresses as risk ratio (RR) and 95% CIs. We used random-effect models with the inverse variance method. We performed subgroup meta-analyses by intervention drug and follow-up period. RESULTS: SGLT2i significantly reduced all-cause mortality (RR: 0.88, 95%CI 0.79-0.98, I2 = 0%), cardiovascular mortality (RR: 0.87, 95%CI 0.77-0.99, I2 = 0%), HF hospitalization (RR: 0.73, 95%CI 0.66-0.81, I2 = 0%) and emergency room visits due to HF (RR: 0.40, 95%CI 0.21-0.76, I2 = 0%), as well as composite outcomes including the previous ones. Besides, it significantly improved the score of the Kansas City Cardiomyopathy Questionnaire (KCCQ, MD: 1.70, 95%CI 1.67-1.73, I2 = 54%). SGLT2i reduced any serious adverse events, blood pressure and weight. However, it increased hematocrit and creatinine. The meta-analysis of RCTs of > 12 weeks of follow-up showed that SGTL2i significantly reduced NT-proBNP. CONCLUSIONS: SGLT2i showed to improve critical outcomes in HF patients, and it is apparently safe.
RESUMO
Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart disease. After more than seven decades of the first palliative surgery, TOF prognosis has changed dramatically. The prevalence of TOF is approximately 3 per 10 000 births, representing 7 to 10% of congenital heart disease. With a higher survival into adulthood, the clinical cardiologist faces challenges in the management of this population, from severe pulmonary regurgitation to heart failure and ventricular arrhythmias. Its prevalence is approximately 3 per 10 000 live births, representing 7 to 10% of congenital heart disease. This review will describe the most relevant aspects of the care of adult patients with this disease.
RESUMO
RESUMEN Objetivo: describir la disponibilidad de los cirujanos cardiovasculares pediátricos e identificar los factores que influyen en la situación de la certificación de esta subespecialidad en el Perú. Materiales y métodos: estudio transversal y descriptivo. Se realizó un muestreo por bola de nieve discriminatorio exponencial partiendo de los cirujanos cardiovasculares pediátricos que trabajan en el Instituto Nacional Cardiovascular hacia abril, 2019. Se solicitó su participación y posteriormente se aplicaron encuestas virtuales. Los datos recolectados de las preguntas cerradas se procesaron con estadísticos descriptivos y los de las preguntas abiertas, en base a su sistematización, orden y relación, obteniéndose así las conclusiones. Resultados: se encuestó a 20 cirujanos. De ellos, 5 refirieron haber estudiado la subespecialidad, teniendo como principales motivaciones una rotación durante el pregrado o la especialidad, y la vocación quirúrgica. Los tres subespecialistas certificados refirieron haberlo realizado debido al deseo de formalizar su práctica quirúrgica en el Perú y los otros dos refirieron no haberlo realizado por falta de tiempo. Asimismo, 11 cirujanos manifestaron el deseo de certificarse. Por otro lado, 17 encuestados refirieron que el Perú necesita más subespecialistas. Conclusión: existe una carencia de oferta de cirujanos cardiovasculares pediátricos en el Perú, lo cual muestra la necesidad de un aumento de las plazas para la subespecialidad; además, aumentar, mejorar y articular los centros resolutivos.
ABSTRACT Objective: to describe availability of pediatric cardiovascular surgeons and to identify factors influencing accreditation for this specialty in Peru. Materials and methods: this is a cross-sectional and descriptive study. A discriminating exponential snowball sampling procedure was performed in pediatric cardiovascular surgeons working in the Peruvian National Cardiovascular Institute. This was carried out in April 2019. Their participation was requested and virtual surveys were carried out. Data collected from closed questions were processed using descriptive statistics. Data from open questions were processed on the basis of their systematization, order, and relationship, so conclusions could be drawn. Results: twenty surgeons were surveyed. Of them, 5 reported having had training for their subspecialty, and they declared their main motivation was having undergone a training period during pregraduate or specialty studies, as well as their interest in surgery. Three accredited subspecialists declared they wanted to formalize their practice in Peru, and the other two declared not having formalized their training because of lack of time. Also, eleven surgeons expressed their desire for achieving accreditation. On the other hand, seventeen surveyed professionals declared that Peru requires more subspecialists. Conclusion: there is lack of pediatric cardiovascular surgeons in Peru; so increasing posts for such subspecialists is necessary, and also there is an urgent need for increasing, improving, and articulating specialized centers.
